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Numerous genetic variants associated with risk for schizophrenia have been identified. However, little is known about how these genes have their effects in the brain. A proof-of-concept study published in the inaugural issue of the journal Biological Psychiatry: Cognitive Neuroscience
5 min read
The U.S. Food and Drug Administration approved Danish drugmaker H. Lundbeck A/S and Japan’s Otsuka Pharmaceutical Co Ltd’s Rexulti, an anti-psychotic drug used to treat schizophrenia. The drug, brexpiprazole, was also approved as an adjunctive therapy for major depressive disorder
3 min read
Although schizophrenia patients with the 22q11.2 gene deletion (22q11.2DS) respond to clozapine (multiple brands) at a lower dose than other patients, they experience more serious adverse events, say Canadian researchers in findings that may pave the way for personalized medicine
6 min read
Childhood-onset schizophrenia is a severe form of psychotic disorder that occurs at age 12 years or younger and is often chronic and persistently debilitating. The definition of childhood schizophrenia has evolved over time and is now believed to be a
21 min read
UK guidelines for treating people diagnosed with schizophrenia currently emphasise the primacy of antipsychotic medication, with or without psychosocially based interventions as circumstances dictate. We now see increasing calls, most notably from mental health service users, for the provision of
34 min read
Intellectual and other more specific neurocognitive impairments in schizophrenia are important for understanding the aetiology of the condition and its likely outcome. However, these impairments are not usually considered important for supporting a diagnosis in suspected early schizophrenia. IQ testing
23 min read
People with schizophrenia make a significant contribution to violence in our communities and, in so doing, often lay waste to their own lives. The 10% or so from which will emerge the perpetrators of most of the serious violence are
37 min read
People with schizophrenia die prematurely. Their illness, its treatment and their lifestyle all contribute to the excess morbidity and mortality. Lifestyle ‘choices’ (e.g. poor diet, low rates of physical activity and increased likelihood to smoke cigarettes) predispose them to poor
35 min read
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